html,body,div,span,applet,object,iframe,h1,h2,h3,h4,h5,h6,p,blockquote,pre,a,abbr,acronym,address,big,cite,code,del,dfn,em,img,ins,kbd,q,s,samp,small,strike,strong,sub,sup,tt,var,b,u,i,center,dl,dt,dd,ol,ul,li,fieldset,form,label,legend,table,caption,tbody,tfoot,thead,tr,th,td,article,aside,canvas,details,embed,figure,figcaption,footer,header,hgroup,menu,nav,output,ruby,section,summary,time,mark,audio,video{vertical-align:baseline;border:0;margin:0;padding:0}article,aside,details,figcaption,figure,footer,header,hgroup,menu,nav,section{display:block}body{line-height:1}blockquote,q{quotes:none}blockquote:before,blockquote:after,q:before,q:after{content:"";content:none}table{border-collapse:collapse;border-spacing:0}*{box-sizing:border-box;outline:none}img{max-width:100%}[data-debug=debug]:after{opacity:.5;color:#fff;z-index:99999;content:"XXL";background:red;border-radius:5px;justify-content:space-around;align-items:center;width:24px;height:24px;padding:5px;font-family:sans-serif;font-size:14px;font-weight:700;line-height:1em;display:flex;position:fixed;bottom:10px;left:10px}@media (width<=1920px){[data-debug=debug]:after{content:"XL"}}@media (width<=1290px){[data-debug=debug]:after{content:"L"}}@media (width<=950px){[data-debug=debug]:after{content:"M"}}@media (width<=768px){[data-debug=debug]:after{content:"S"}}@media (width<=576px){[data-debug=debug]:after{content:"XS"}}:export{L:1290;M:950;S:768;XS:576}.topbar{border-bottom:1px solid #ffffff14;background:#0f0f10!important}.topbar .topbar-inner{width:100%;padding:0 24px}.topbar .toolbar{justify-content:space-between;gap:16px;min-height:68px;display:flex}.topbar .logo{color:#fff;letter-spacing:.08em;flex-shrink:0;font-weight:700;text-decoration:none}.topbar .desktop-nav{align-items:center;gap:6px;margin-left:auto;display:none}.topbar .mobile-nav{margin-left:auto;display:flex}.topbar .nav-link{color:#ffffffe6;text-transform:none;border-radius:10px;padding:8px 12px;font-weight:500}.topbar .nav-link:hover{background:#ffffff14}.topbar .nav-link.active{color:#fff;background:#ffffff24}.topbar .report-link{color:#fff}@media (width>=980px){.topbar .desktop-nav{display:flex}.topbar .mobile-nav{display:none}}.report-dialog .dialog-content{flex-direction:column;gap:20px;padding-top:8px;display:flex}.report-dialog .dialog-text{color:#555}.report-dialog .captcha-box{flex-direction:column;gap:12px;display:flex}.report-dialog .captcha-placeholder{text-align:center;letter-spacing:.08em;color:#555;background:#f7f8fa;border:1px dashed #b6bcc6;border-radius:12px;padding:18px;font-weight:600}.page{width:100%;padding:0 24px}.page .card{background:#fff;border:1px solid #e8eaee;border-radius:18px;width:100%;padding:32px}.page .form-card .form-grid{flex-direction:column;gap:16px;margin-top:20px;display:flex}.page .page-title{margin-bottom:12px;font-weight:700}.page .page-text{color:#4d5562;line-height:1.7}.report-dialog-content{flex-direction:column;gap:16px;display:flex;padding-top:8px!important}.report-dialog-title{font-weight:700!important}.report-dialog-text{line-height:1.7}.report-dialog-field{margin-top:4px}.report-dialog-captcha{justify-content:flex-start;height:100px;display:flex}.report-dialog-alert{margin-top:4px}.report-dialog-actions{padding:16px 24px 20px!important}@media (width<=600px){.report-dialog-captcha{transform-origin:0 0}}html,body,#root{min-height:100%}body{color:#111;background:#f5f6f8;font-family:Inter,system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,sans-serif}*{box-sizing:border-box}a{color:inherit}.app-shell{min-height:100vh}.page-shell{padding:32px 0 48px}.home-page{flex-direction:column;gap:24px;display:flex}.home-hero{flex-direction:column;gap:24px;padding:32px;display:flex}.home-hero-copy{flex-direction:column;gap:16px;display:flex}.home-lead{max-width:980px;line-height:1.8!important}.home-search{align-items:stretch;gap:12px;display:flex}.home-search-field{flex:1}.home-search-button{min-width:140px}.home-stats{grid-template-columns:repeat(3,minmax(0,1fr));gap:16px;display:grid}.home-stat-card{padding:24px}.home-stat-value{font-size:32px!important;font-weight:700!important;line-height:1.1!important}.home-stat-label{color:#6b7280;margin-top:8px!important}.home-chart-grid{grid-template-columns:repeat(3,minmax(0,1fr));gap:16px;display:grid}.home-pie-card{min-width:0;padding:24px}.home-card-title{font-weight:700!important}.home-card-subtitle{color:#6b7280;margin-top:6px!important;margin-bottom:16px!important}.home-pie-wrap{width:100%;overflow:hidden}.home-karyo-card{padding:28px 32px}.home-karyo-top{justify-content:space-between;align-items:flex-start;gap:16px;display:flex}.home-karyo-heading{flex-direction:column;display:flex}.home-karyo-controls{min-width:220px}.home-select-control{width:100%}.home-karyo-meta{color:#4b5563;gap:24px;margin-top:20px;margin-bottom:20px;font-weight:600;display:flex}.home-karyo-map{width:100%;min-height:180px}#tooltip{color:#222;opacity:0;background:#fff;border:1px solid #0000004d;border-radius:3px;max-width:200px;padding:8px 12px;font-size:12px;position:absolute;box-shadow:0 2px 5px #0003}#tooltip p{margin:0;line-height:1.2em}#tooltip p.gene{margin-bottom:2px;font-weight:700}.karyotype-svg .chr-border{fill:#0000;stroke-width:1px;stroke:#111}.karyotype-svg line.karyo-hints{stroke:#000;stroke-width:1px}.karyotype-svg text.karyo-hints{font-size:10px}.karyotype-svg pattern line{stroke:red;stroke-width:.7px}.karyotype-svg rect.selection{stroke:#a00;fill:red;stroke-width:1px;transform:translateY(-2px)}.home-note-card{padding:20px 24px}.home-note-text{line-height:1.8!important}.home-note-link{text-decoration:none}.home-note-link:hover{text-decoration:underline}.home-empty{color:#6b7280;padding:20px 0;line-height:1.7}.karyotype-svg{max-width:100%;display:block}.karyotype-tooltip{z-index:20;pointer-events:none;background:#fff;border:1px solid #0f172a1f;border-radius:10px;min-width:180px;max-width:280px;padding:10px 12px;transition:opacity .15s;position:absolute;box-shadow:0 10px 30px #0f172a1f}.karyotype-tooltip-gene{margin:0 0 4px;font-weight:700}.karyotype-tooltip-level{color:#475569;margin:0 0 4px}.karyotype-tooltip-desc{color:#475569;margin:0;line-height:1.5}.chr-border{fill:none;stroke:#222;stroke-width:1.25px}.karyo-hints{fill:#475569;stroke:#94a3b8;stroke-width:1px;font-size:10px}.karyotype-marker{cursor:default}.karyotype-marker:hover{stroke:#111827;stroke-width:1.5px}.axis--x path{stroke:#94a3b8}.axis--x line{stroke:#cbd5e1}.axis--x text{fill:#64748b;font-size:10px}@media (width<=1100px){.home-chart-grid,.home-stats{grid-template-columns:1fr}}@media (width<=800px){.home-hero,.home-karyo-card{padding:24px}.home-search{flex-direction:column}.home-search-button{width:100%}.home-karyo-top{flex-direction:column}.home-karyo-controls{width:100%;min-width:0}.home-karyo-meta{flex-direction:column;gap:8px}}@media (width<=600px){.home-page{gap:16px}.home-hero,.home-karyo-card,.home-pie-card,.home-stat-card{padding:20px}.home-note-card{padding:18px 20px}}.collection-page{flex-direction:column;gap:16px;width:100%;padding:0 24px;display:flex}.collection-page h1{margin:0;font-size:1.75rem;line-height:1.2}.collection-page .collection-header{flex-wrap:wrap;justify-content:space-between;align-items:flex-start;gap:16px;display:flex}.collection-page .collection-tools{flex-wrap:wrap;align-items:center;gap:12px;display:flex}.collection-page .collection-tools .quick-search{min-width:240px}.collection-page .filter-list{flex-direction:column;gap:12px;display:flex}.collection-page .filter-row{background:#fff;border:1px solid #e7e9ee;border-radius:14px;flex-wrap:wrap;align-items:center;gap:12px;padding:12px;display:flex}.collection-page .filter-control{min-width:180px}.collection-page .field-control{min-width:220px}.collection-page .operator-control{min-width:180px}.collection-page .value-control{flex:260px;min-width:220px}.collection-page .filter-empty{color:#667085;padding:0 8px;font-size:.95rem}.collection-page .filter-remove{margin-left:auto}.collection-page .grid-card{overflow:hidden}.collection-page .cell-value{text-overflow:ellipsis;white-space:nowrap;width:100%;display:block;overflow:hidden}.dialog-title{border-bottom:1px solid #eee;justify-content:space-between;display:flex}.record-dialog .details-grid{flex-direction:column;gap:14px;padding-top:8px;display:flex}.record-dialog .details-row{border-bottom:1px solid #eef1f5;grid-template-columns:290px 1fr;align-items:start;gap:16px;padding-bottom:12px;display:grid}.record-dialog .details-label{color:#101828;font-weight:600}.record-dialog .details-value{white-space:pre-wrap;word-break:break-word;color:#344054}@media (width<=900px){.collection-page .record-dialog .details-row{grid-template-columns:1fr;gap:8px}}.cell-with-bullet{align-items:center;gap:8px;width:100%;min-width:0;display:inline-flex}.cell-bullet{background:var(--bullet-color,#999);border-radius:999px;width:10px;min-width:10px;height:10px}.cell-fill{background:var(--cell-bg,transparent);width:calc(100% + 16px);height:calc(100% + 16px);color:var(--cell-fg,inherit);align-items:center;margin:-8px;padding:0 8px;font-weight:500;display:flex}.related-list{flex-direction:column;gap:20px;margin-top:24px;display:flex}.related-section{flex-direction:column;gap:10px;display:flex}.related-title{margin:0;font-size:1.1rem;font-weight:700}.view-button{color:#475467;background:#fff;border:1px solid #d9dee7;width:32px;height:32px}.view-button:hover{background:#f5f7fa}.extra-status-bar{background:#fff3bf;border:1px solid #0000001a;border-radius:4px;align-items:center;gap:20px;padding:2px 18px;display:flex}.extra-status-title{color:#5f4b00;min-width:190px;font-weight:700}.extra-status-options{flex-wrap:wrap;gap:2px 14px;display:flex}.extra-status-option{margin:0!important}.extra-status-option .MuiFormControlLabel-label{font-size:14px}@media (width<=900px){.extra-status-bar{flex-direction:column;gap:10px}.extra-status-title{min-width:0;padding-top:0}}.about-page{flex-direction:column;gap:24px;display:flex}.about-hero{padding:32px}.about-section{padding:28px 32px}.about-section-title{margin-bottom:16px!important;font-weight:700!important}.about-text{line-height:1.8!important}.about-link{word-break:break-word;margin-top:4px;display:inline-block}.about-list{margin:0;padding-left:22px}.about-list-item{margin-bottom:10px;line-height:1.8}.about-group{margin-top:8px}.about-subtitle{margin-bottom:8px!important;font-weight:700!important}.about-strong{font-weight:700}@media (width<=900px){.about-hero,.about-section{padding:24px}}@media (width<=600px){.about-page{gap:16px}.about-hero,.about-section{padding:20px}.about-list{padding-left:18px}}.submit-page{flex-direction:column;gap:24px;display:flex}.submit-page .MuiFormControlLabel-root{max-width:500px}.submit-hero{padding:32px}.submit-card{padding:28px 32px}.submit-text{line-height:1.8!important}.submit-grid{flex-direction:column;gap:16px;display:flex}.submit-row{align-items:center;gap:16px;display:flex}.submit-upload-button{flex-shrink:0;min-width:160px}.submit-file-box{flex:1;min-width:0}.submit-file-name{word-break:break-word;line-height:1.7;display:inline-block}.submit-file-hint{flex-wrap:wrap;align-items:center;gap:10px;line-height:1.7;display:flex}.submit-file-empty{color:#6b7280}.submit-example-link{text-decoration:none}.submit-example-link:hover{text-decoration:underline}.submit-captcha{justify-content:flex-start;height:100px;margin-top:24px;display:flex;overflow-x:auto}.submit-consent{margin-top:20px;align-items:flex-start!important}.submit-alert{margin-top:16px}.submit-actions{justify-content:flex-start;margin-top:20px;display:flex}@media (width<=900px){.submit-hero,.submit-card{padding:24px}}@media (width<=700px){.submit-row{flex-direction:column;align-items:stretch;gap:10px}.submit-upload-button{width:100%;min-width:0}}@media (width<=600px){.submit-page{gap:16px}.submit-hero,.submit-card{padding:20px}}